TruthNexus
Clinical Outcomes · Coming Soon

FDA-deliverable outcomes evidence without building from scratch

Every healthcare AI company that pursues serious enterprise sales or FDA submission eventually needs a paired-clinician outcomes study — pre-registered, IRB-approved, blinded reviewer panel, reproducible statistics. Building it from scratch costs six-figure budgets and 9–12 months. Skippy Outcomes Eval sells the methodology Skippy built for its own clinical-value evaluation: pre-validated protocol templates, 50+ board-certified reviewers, reproducible analysis pipelines, and FDA SaMD-formatted output. First, we prove it on ourselves. Then we sell it.

The Evidence Gap

Accuracy benchmarks don't answer the outcomes question

FDA SaMD pre-submissions, EU AI Act high-risk-system conformity, and serious enterprise health-system pilots all eventually ask: “Show me evidence that using your AI improves clinical decisions.” LLM accuracy benchmarks don't answer that. Citation-grounding benchmarks don't answer that. The answer is a paired-clinician decision-quality study with blinded expert review, pre-registered hypotheses, and IRB-approved protocol.

4–6 weeks
Study design, from scratch
4–8 weeks
IRB review cycle
Six-figure
Typical from-scratch build cost

Skippy Outcomes Eval reduces IRB review to 4–6 weeks and total time-to-completion to 5–8 months — by starting from proven-acceptable templates rather than building from scratch.

What's Included

Every component needed for FDA-grade outcomes evidence

Pre-registered protocol template

The OSF/ClinicalTrials.gov registration template built for Skippy's own clinical-value study — customized per engagement. Primary hypothesis structure, within-subjects paired design, sample-size calculator, and pre-specified analysis plan. Customers customize ~15%; the rest is proven-acceptable by prior IRB reviews.

IRB protocol package

Pre-formatted IRB submission documents: protocol synopsis, informed consent template, recruitment materials, data-management plan, risk/benefit analysis. Reduces IRB approval time from 8+ weeks to 4–6 weeks because reviewers see a familiar, structurally sound protocol.

50+ board-certified reviewer panel

Skippy maintains a network of 50+ board-certified clinicians across primary care, oncology, cardiology, psychiatry, and emergency medicine. Per-engagement assignment with blinding enforcement. Inter-rater reliability (κ ≥ 0.7) required before scoring begins.

Pre-validated statistical analysis pipelines

Reproducible analysis containers: paired t-test + Wilcoxon fallback, bootstrap 95% CIs (1,000 resamples), Cohen's κ + Krippendorff's α for inter-rater reliability, Holm-corrected subgroup analysis, and pre-registered sensitivity analyses. Every engagement runs the same containers — output is bit-identical for fixed inputs.

Five-dimension decision-quality rubric

Accuracy, citation appropriateness, uncertainty acknowledgment, boundary recognition, and patient-context integration — a vendored rubric customizable per use case. Domain-specific dimensions available for oncology, primary care, and psychiatry engagements.

FDA-deliverable output format

Final analysis formatted to match FDA SaMD clinical-evaluation submission expectations. Pre-registration reference, blinded reviewer panel provenance, statistical analysis containers, and deviation documentation — structured to LOI → Qualification Plan → Data Submission workflow.

Engagement Tiers

Sized to your study requirements

TierScopePriceTimeline
PilotSingle specialty · 100 paired casesCustom5–6 months
StandardMulti-specialty · 200–400 paired casesCustom6–8 months
EnterpriseMulti-site · 400–800 paired cases · multi-IRBCustom7–10 months
Annual repeatRepeat study, prior methodology reusedCustom4–6 months

Compares favorably to from-scratch build cost for equivalent quality.

Who It's For

Healthcare AI companies that need to show their evidence

Healthcare AI startups (Series B+) preparing FDA submissions
Pre-registration + blinded reviewer panel + analysis containers reduce outcomes-study build cost by 60–80% and time-to-completion from 9–12 months to 5–8.
Mature healthcare AI vendors
Ongoing study program aligned to Algorithm Change Protocol versioning. Each major release has its own pre-registered outcomes record — the evidence backbone for enterprise sales.
Pharma digital-therapeutics divisions
The same methodology covers non-AI medical software. Digital therapeutic trials, DTx FDA Pre-Cert–style evaluations, and software-component clinical validation all map to this framework.
Academic medical centers running AI-eval studies
Standardized protocol templates reduce cross-study protocol drift. Using a common framework improves comparability across the growing body of clinical-AI evaluation literature.
Methodology integrity

Skippy Outcomes Eval will not be available until Skippy has completed its own outcomes study and published the results. Selling methodology before using it yourself is hollow. The pre-registration, reviewer panel, and analysis pipelines are built for Skippy's own clinical-value evaluation first — per SWOT plan 15. The first external customer engagement begins only after that paper is published. Protocol templates will be open-sourced on OSF. The value is the panel, the execution, and the analysis infrastructure — not the template.

Need outcomes evidence for your healthcare AI?

Join the waitlist. We sequence pilots after Skippy's own outcomes paper publishes.