TruthNexus
Live · 143 sources · 9 products · 4 coming soon

Medical

Clinical evidence, genomics, pharmacology, oncology, and rare disease — ingested from 143 authoritative sources, cross-validated, and calibrated. Nine products live across medication safety, drug discovery, clinical evidence, genomics, and more.

143
Ingest sources
1B+
Data points indexed
3M+
Verified findings
9
Live products
Live Products

Available now

Skippy Ground

Claim Verification

Verify any medical claim against Skippy's evidence base. Returns a calibrated confidence score, source citations, and surfaces contradictions. The evidence verification layer for healthcare AI.

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Skippy Auth

Prior Authorization

Evidence-grounded prior authorization intelligence. Given drug + diagnosis, returns a fully auditable recommendation with source lineage — defensible to CMS.

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Skippy Variants

Genomics

Genomic variant interpretation with ACMG/AMP criteria applied programmatically. Built on 2.8M ClinVar records. Continuous monitoring for reclassification-warranting evidence changes.

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Skippy Med-Check

Medication Safety

Medication safety intelligence for health plans, PBMs, and consumer health apps. Drug interactions, side effect attribution, and pharmacogenomics — grounded, not hallucinated.

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Skippy Rare

Rare Disease

Phenotype matching, variant evidence, natural history synthesis, and trial intelligence in one platform. 300M people have rare diseases; 90% wait years for a diagnosis.

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Skippy Integrity

Clinical Fraud Prevention

Pre-payment clinical plausibility screening for Medicaid and Medicare fraud detection. Evidence-grounded claim and regimen verification with OIG-ready audit records.

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Skippy DDI

Drug Interactions

Mechanistic drug-drug interaction analysis grounded in pharmacology evidence. CYP enzyme, transporter, and QT prolongation interactions with CPIC-aligned clinical action guidance.

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Skippy Clinical

Clinical Decision Support

Real-time order verification, treatment protocol guidance, and discharge summary review — FHIR R4 native, CDS Hooks compatible, evidence-grounded at every step.

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Skippy Pharmacogenomics

Pharmacogenomics

Gene-drug interaction guidance for 24+ actionable gene-drug pairs. CYP2C19, CYP2D6, DPYD, and TPMT clinical action recommendations — CPIC and PharmGKB aligned.

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Skippy Pharmacovigilance

Drug Safety

Cross-validate adverse event signals across FAERS, OnSIDES, and VAERS against pharmacology evidence. Detect emerging safety signals months before label updates.

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Skippy Drug Discovery

R&D Intelligence

Drug repurposing intelligence grounded in ChEMBL, pathway data, and clinical evidence. Identifies novel indications with calibrated confidence and tamper-evident prediction records.

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Skippy Biomarker

Biomarker Analysis

Biomarker validation across genomics, expression, and clinical evidence sources. FDA/EMA qualification status, companion diagnostic alignment, and trial enrollment correlation.

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Skippy Trial Design

Clinical Trials

Patient matching, endpoint analysis, and site selection for clinical trials. Searches 578K+ ClinicalTrials.gov records with eligibility matching and investigator identification.

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Skippy Medical Coding

Medical Coding

Pre-submit CPT/ICD-10 verification against NCD/LCD coverage policies. Evidence-grounded denial prediction and appeal support before claims go to payer.

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Skippy Pharma Compliance

Pharma Marketing

FDA off-label claim detection, fair balance scoring, and evidence verification for promotional materials — before MLR submission, before OPDP enforcement.

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Skippy CDSS Marketplace

CDS Rules

Pre-built, evidence-calibrated clinical decision support rules deployable to Epic and Cerner via CDS Hooks. Browse, customize, and deploy validated rules in hours.

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Sources

What we ingest

Every source is ingested, normalized, and cross-validated. Provenance is preserved at every layer — nothing is a black box.

Clinical Literature
PubMed · bioRxiv · Cochrane · PubTator3
1 billion+ data points indexed and cross-referenced
Genomics & Variants
ClinVar · gnomAD · GWAS Catalog · HGNC · dbSNP
736K+ curated variants, population frequencies
Drug & Pharmacology
ChEMBL · DrugBank · DailyMed · RxNorm · PharmGKB
2.3M+ bioactive compounds, PGx guidelines
Proteins & Pathways
UniProt · Reactome · STRING · BioGRID · IntAct
20.4K reviewed proteins, 1.26M interactions
Oncology
TCGA · cBioPortal · CIViC · DepMap · COSMIC
Somatic mutations, cancer dependencies, variant interpretations
Disease Ontologies
MONDO · HPO · Orphanet · DisGeNET
Unified rare disease classification, gene-phenotype associations
Adverse Events & Safety
FAERS · OnSIDES · VAERS · CTD
FDA adverse event reporting, label-derived side effects
Clinical Trials
ClinicalTrials.gov
578K+ registered studies — eligibility, endpoints, status
The evidence quality problem
“50–90% of medical AI responses are not fully supported by their own cited sources — sometimes contradicted by them.”

Stanford SourceCheckup, Nature Communications, Apr 2025 · 800 questions × ~58K statement-source pairs across 7 LLMs

Skippy's verifier rejects ungrounded output as a hard contract. The citation target is a verified finding with calibrated confidence and full source lineage — not a paper, chunk, or URL.

Health System Delivery

Embedded in your EHR — not alongside it

Skippy integrates at the point of care via CDS Hooks — the HL7 standard for real-time clinical decision support inside EHR workflows. Clinicians receive evidence-grounded alerts without leaving their chart.

patient-view
Chart open

Surface pharmacogenomic alerts, contraindications, and missed screening recommendations as a clinician opens the patient record.

medication-prescribe
Prescription

Drug–drug interaction checks, pharmacogenomic dosing guidance, and evidence-grounded alternatives at prescribing time.

order-review
Order entry

Evidence-based appropriateness checks at order entry — flag duplicate tests, off-guideline orders, and high-risk combinations.

FHIR R4
Native FHIR format
< 90 days
Signed agreement → live in Epic
App Orchard
Epic listing in progress

See Skippy in your clinical workflow

We work with health systems, life sciences companies, and clinical informatics teams. Let's talk about your evidence problem.

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